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© 2009 Chinese Optics Letters
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   Home  List of Issues    Issue 01 , Vol. 01 , 2003    Article Abstract

Measurement of optical penetration depth and refractive index of human tissue
Shusen Xie, Hui Li, and Buhong Li
Chinese Optics Letters , Vol.01 , Issue 01 , PP.44-44(2003)

Keywords(OCIS Code)
170.0170 (medical optics and biotechnology), 170.6930 (tissue), 160.4760 (optical properties).

Abstract
Experimental techniques for measurement of optical penetration depth and refractive index of human tissue are presented, respectively. Optical penetration depth can be obtained from the measurement of the relative fluence-depth distribution inside the target tissue. The depth of normal and carcinomatous human lung tissues irradiated with the wavelengths of 406.7, 632.8 and 674.4 nm in vitro are respectively determined. In addition, a novel simple method based on total internal reflection for measuring the refractive index of biotissue in vivo is developed, and the refractive indices of skin from people of different age, sex and skin color are measured. Their refractive indices are almost same and the average is 1.533.

©2003-2007 Chinese Optics Letters

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Manuscript Accepted:2002-6-25
Revised Manuscript:
Published :


Column:medical optics and biotechnology
Note: This work was supported by the National Natural Science Foundation of China under Grant No. 60178022 and the Fujian Provincial Natural Science Foundation under Grant No. 2002F008. S. Xie is the author to whom the correspondence should be addressed, his e-mail address is ssxie@fjnu.edu.cn.

References

1. A. J. Welch and M. J. C. van Gemert, Optical-Thermal Response of Laser-Irradiated Tissue (Plenum Press, New York, 1995), p. 233.

2. W. M. Star, Phys. Med. Bio. 42, 763 (1997).

3. S. L. Jacques, Proc. SPIE 1645, 155 (1992).

4. S. S. Xie, H. Li, and Z. K. Lu, Physics (in Chinese) 27, 599 (1998).

5. W. F. Cheong, S. A. Prahl, and A. J. Welch, IEEE J. Quantum Electron. 26, 2166 (1990).

6. F. P. Bolin, L. E. Preuss, and R. C. Taylor, Appl. Opt. 28, 2297 (1989).

7. H. Li and S. S. Xie, Appl. Opt. 35, 1793 (1996).